With the continuous expansion of the dimension of systematic combat confrontation and the gradual deepening of the degree of multi-domain cooperation， air and space strength is becoming the key to determine the victory of future wars. In this paper， the combat concept of the air and space integrated operation system is proposed. The composition and typical combat patterns of the air and space integrated operation system are discussed， and the key technologies involved are analyzed， which can provide support for the construction of the air and space integrated operation system in the future.